| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50119676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_65490 |
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| IC50 | 0.120000±n/a nM |
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| Citation |  Niiyama, K; Takahashi, H; Nagase, T; Kojima, H; Amano, Y; Katsuki, K; Yamakawa, T; Ozaki, S; Ihara, M; Yano, M; Fukuroda, T; Nishikibe, M; Ishikawa, K Structure-Activity relationships of 2-substituted 5,7-Diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acids as a novel class of endothelin receptor antagonists. Bioorg Med Chem Lett12:3041-5 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48736.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25101 |
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| Residue: | 427 |
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| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
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| BDBM50119676 |
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| n/a |
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| Name | BDBM50119676 |
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| Synonyms: | (R)-5-Benzo[1,3]dioxol-5-yl-7-(4-methoxy-phenyl)-2-propylamino-6,7-dihydro-5H-[1]pyrindine-6-carboxylic acid | CHEMBL432012 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N2O5 |
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| Mol. Mass. | 446.495 |
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| SMILES | CCCNc1ccc2[C@@H]([C@H]([C@@H](c2n1)c1ccc(OC)cc1)C(O)=O)c1ccc2OCOc2c1 |
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| Structure | 
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