| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50119713 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_85525 |
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| Ki | 22000±n/a nM |
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| Citation |  Vasudevan, A; Conner, SE; Gentles, RG; Faghih, R; Liu, H; Dwight, W; Ireland, L; Kang, CH; Esbenshade, TA; Bennani, YL; Hancock, AA Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett12:3055-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40115.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 359 |
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| Sequence: | MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
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|
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| BDBM50119713 |
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| n/a |
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| Name | BDBM50119713 |
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| Synonyms: | (S)-N-{(S)-1-[3-(4-Acetyl-phenoxy)-propyl]-pyrrolidin-3-yl}-2-amino-3-hydroxy-propionamide | CHEMBL104994 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H27N3O4 |
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| Mol. Mass. | 349.4247 |
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| SMILES | CC(=O)c1ccc(OCCCN2CC[C@@H](C2)NC(=O)[C@@H](N)CO)cc1 |
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| Structure | 
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