| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50119739 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_87253 |
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| Ki | 19±n/a nM |
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| Citation |  Vasudevan, A; Conner, SE; Gentles, RG; Faghih, R; Liu, H; Dwight, W; Ireland, L; Kang, CH; Esbenshade, TA; Bennani, YL; Hancock, AA Synthesis and evaluation of potent pyrrolidine H(3) antagonists. Bioorg Med Chem Lett12:3055-8 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50119739 |
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| n/a |
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| Name | BDBM50119739 |
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| Synonyms: | CHEMBL102794 | {4-[3-((1S,4S)-5-Benzenesulfonyl-2,5-diaza-bicyclo[2.2.1]hept-2-yl)-propoxy]-phenyl}-cyclopropyl-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O4S |
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| Mol. Mass. | 440.555 |
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| SMILES | O=C(C1CC1)c1ccc(OCCCN2C[C@@H]3C[C@H]2CN3S(=O)(=O)c2ccccc2)cc1 |
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| Structure | 
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