| Reaction Details |
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 | Report a problem with these data |
| Target | Vasopressin V2 receptor |
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| Ligand | BDBM50119813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_214854 (CHEMBL821469) |
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| Ki | 9±n/a nM |
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| Citation |  Dyatkin, AB; Hoekstra, WJ; Hlasta, DJ; Andrade-Gordon, P; de Garavilla, L; Demarest, KT; Gunnet, JW; Hageman, W; Look, R; Maryanoff, BE Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity. Bioorg Med Chem Lett12:3081-4 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Vasopressin V2 receptor |
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| Name: | Vasopressin V2 receptor |
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| Synonyms: | ADHR | AVPR V2 | AVPR2 | Antidiuretic hormone receptor | DIR | DIR3 | Renal-type arginine vasopressin receptor | V2R | V2R_HUMAN | VASOPRESSIN V2 | Vasopressin V2 receptor | Vasopressin receptor |
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| Type: | Receptor |
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| Mol. Mass.: | 40295.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30518 |
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| Residue: | 371 |
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| Sequence: | MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA
ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM
VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ
RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP
SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA
PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT
ASSSLAKDTSS
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| BDBM50119813 |
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| n/a |
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| Name | BDBM50119813 |
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| Synonyms: | 1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-trifluoromethylbenzamide | CHEMBL320416 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H25ClF3N3O2 |
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| Mol. Mass. | 539.976 |
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| SMILES | FC(F)(F)c1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1C[C@@H]2C3CCC(C3)N2Cc2cc(Cl)ccc12 |TLB:22:23:28:26.25,THB:30:29:28:26.25| |
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| Structure | 
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