| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vasopressin V1a receptor |
|---|
| Ligand | BDBM50119813 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_214407 (CHEMBL820272) |
|---|
| IC50 | 4±n/a nM |
|---|
| Citation |  Dyatkin, AB; Hoekstra, WJ; Hlasta, DJ; Andrade-Gordon, P; de Garavilla, L; Demarest, KT; Gunnet, JW; Hageman, W; Look, R; Maryanoff, BE Bridged bicyclic vasopressin receptor antagonists with V(2)-selective or dual V(1a)/V(2) activity. Bioorg Med Chem Lett12:3081-4 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vasopressin V1a receptor |
|---|
| Name: | Vasopressin V1a receptor |
|---|
| Synonyms: | AVPR V1a | AVPR1 | AVPR1A | Antidiuretic hormone receptor 1a | V1AR_HUMAN | V1aR | VASOPRESSIN V1A | Vascular/hepatic-type arginine vasopressin receptor | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 46820.18 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P37288 |
|---|
| Residue: | 418 |
|---|
| Sequence: | MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAV
TFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGP
DWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFV
LSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFIC
YNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAY
IVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCV
QSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST
|
|
|
|---|
| BDBM50119813 |
|---|
| n/a |
|---|
| Name | BDBM50119813 |
|---|
| Synonyms: | 1N-{4-[6-chloro-16-methyl-(12S)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-trien-10-ylcarbonyl]phenyl}-2-trifluoromethylbenzamide | CHEMBL320416 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H25ClF3N3O2 |
|---|
| Mol. Mass. | 539.976 |
|---|
| SMILES | FC(F)(F)c1ccccc1C(=O)Nc1ccc(cc1)C(=O)N1C[C@@H]2C3CCC(C3)N2Cc2cc(Cl)ccc12 |TLB:22:23:28:26.25,THB:30:29:28:26.25| |
|---|
| Structure | 
|
|---|
Search and Browse
