Reaction Details |
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Target | D(4) dopamine receptor |
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Ligand | BDBM50119882 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_58962 (CHEMBL669519) |
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Ki | 31±n/a nM |
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Citation | Zhao, H; Thurkauf, A; He, X; Hodgetts, K; Zhang, X; Rachwal, S; Kover, RX; Hutchison, A; Peterson, J; Kieltyka, A; Brodbeck, R; Primus, R; Wasley, JW Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships. Bioorg Med Chem Lett12:3105-9 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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D(4) dopamine receptor |
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Name: | D(4) dopamine receptor |
Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
Type: | Enzyme |
Mol. Mass.: | 48373.19 |
Organism: | Homo sapiens (Human) |
Description: | P21917 |
Residue: | 419 |
Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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BDBM50119882 |
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n/a |
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Name | BDBM50119882 |
Synonyms: | 2-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-(2,2-diethyl-2,3-dihydro-indol-1-yl)-ethanone | CHEMBL326250 |
Type | Small organic molecule |
Emp. Form. | C25H32ClN3O |
Mol. Mass. | 425.994 |
SMILES | CCC1(CC)Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(Cl)cc2)CC1 |
Structure |
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