| Reaction Details |
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 | Report a problem with these data |
| Target | D(4) dopamine receptor |
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| Ligand | BDBM50119920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_62966 |
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| Ki | 5±n/a nM |
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| Citation |  Zhao, H; Thurkauf, A; He, X; Hodgetts, K; Zhang, X; Rachwal, S; Kover, RX; Hutchison, A; Peterson, J; Kieltyka, A; Brodbeck, R; Primus, R; Wasley, JW Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships. Bioorg Med Chem Lett12:3105-9 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(4) dopamine receptor |
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| Name: | D(4) dopamine receptor |
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| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 48373.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21917 |
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| Residue: | 419 |
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| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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| BDBM50119920 |
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| n/a |
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| Name | BDBM50119920 |
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| Synonyms: | 1-(2-Methyl-2,3-dihydro-indol-1-yl)-2-[4-(4-trifluoromethoxy-benzyl)-piperazin-1-yl]-ethanone | CHEMBL106208 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26F3N3O2 |
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| Mol. Mass. | 433.4666 |
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| SMILES | CC1Cc2ccccc2N1C(=O)CN1CCN(Cc2ccc(OC(F)(F)F)cc2)CC1 |
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| Structure | 
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