| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lck |
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| Ligand | BDBM50120127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_96910 |
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| IC50 | 3±n/a nM |
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| Citation |  Chen, P; Iwanowicz, EJ; Norris, D; Gu, HH; Lin, J; Moquin, RV; Das, J; Wityak, J; Spergel, SH; de Fex, H; Pang, S; Pitt, S; Shen, DR; Schieven, GL; Barrish, JC Synthesis and SAR of novel imidazoquinoxaline-based Lck inhibitors: improvement of cell potency. Bioorg Med Chem Lett12:3153-6 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase Lck |
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| Name: | Tyrosine-protein kinase Lck |
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| Synonyms: | 2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase |
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| Type: | n/a |
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| Mol. Mass.: | 57987.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06239 |
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| Residue: | 509 |
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| Sequence: | MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
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| BDBM50120127 |
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| n/a |
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| Name | BDBM50120127 |
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| Synonyms: | CHEMBL106213 | N*4*-(2-Chloro-6-methyl-phenyl)-N*7*-(2-dimethylamino-ethyl)-8-methoxy-1-methyl-imidazo[1,5-a]quinoxaline-4,7-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27ClN6O |
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| Mol. Mass. | 438.953 |
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| SMILES | COc1cc2c(cc1NCCN(C)C)nc(Nc1c(C)cccc1Cl)c1cnc(C)n21 |
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| Structure | 
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