Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50120345 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_37065 |
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Ki | 96±n/a nM |
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Citation | Pacofsky, GJ; Stafford, JA; Cox, RF; Cowan, JR; Dorsey, GF; Gonzales, SS; Kaldor, I; Koszalka, GW; Lovell, GG; McIntyre, MS; Tidwell, JH; Todd, D; Whitesell, G; Wiard, RP; Feldman, PL Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists. Bioorg Med Chem Lett12:3219-22 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50120345 |
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n/a |
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Name | BDBM50120345 |
Synonyms: | 3-[(S)-7-Chloro-5-(2-fluoro-phenyl)-2-methylamino-3H-benzo[e][1,4]diazepin-3-yl]-propionic acid methyl ester | CHEMBL109507 |
Type | Small organic molecule |
Emp. Form. | C20H19ClFN3O2 |
Mol. Mass. | 387.835 |
SMILES | CNC1=Nc2ccc(Cl)cc2C(=N[C@H]1CCC(=O)OC)c1ccccc1F |c:12,t:2| |
Structure |
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