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Reaction Details
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TargetTranslocator protein
LigandBDBM50120361
Substrate/Competitorn/a
Meas. Tech.ChEBML_37065
Ki 1075±n/a nM
Citation Pacofsky, GJStafford, JACox, RFCowan, JRDorsey, GFGonzales, SSKaldor, IKoszalka, GWLovell, GGMcIntyre, MSTidwell, JHTodd, DWhitesell, GWiard, RPFeldman, PL Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists. Bioorg Med Chem Lett12:3219-22 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Translocator protein
Name:Translocator protein
Synonyms:Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:Mitochondrion membrane protein
Mol. Mass.:18945.84
Organism:Rattus norvegicus (rat)
Description:Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50120361
n/a
NameBDBM50120361
Synonyms:3-((S)-7-Chloro-2-methylamino-5-pyridin-2-yl-3H-benzo[e][1,4]diazepin-3-yl)-propionic acid methyl ester | CHEMBL111701
TypeSmall organic molecule
Emp. Form.C19H19ClN4O2
Mol. Mass.370.833
SMILESCNC1=Nc2ccc(Cl)cc2C(=N[C@H]1CCC(=O)OC)c1ccccn1 |c:12,t:2|
Structure
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