Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetGhrelin receptor
LigandBDBM50120504
Substrate/Competitorn/a
Meas. Tech.ChEBML_89487
Ki 0.450000±n/a nM
Citation Carpino PALefker BAToler SMPan LCHadcock JRMurray MCCook ERDiBrino JNDeNinno SLChidsey-Frink KLHada WAInthavongsay JLewis SKMangano FMMullins MANickerson DFNg OPirie CMRagan JARose CRTess DAWright ASYu LZawistoski MPPettersen JCDaSilva-Jardine PAWilson TCThompson DD Discovery and biological characterization of capromorelin analogues with extended half-lives. Bioorg Med Chem Lett 12:3279-82 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Ghrelin receptor
Name:Ghrelin receptor
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50120504
n/a
NameBDBM50120504
Synonyms:2-Amino-N-[(R)-2-[3a-benzyl-3-oxo-2-(2,2,2-trifluoro-ethyl)-2,3,3a,4,6,7-hexahydro-pyrazolo[4,3-c]pyridin-5-yl]-1-(3,4-difluoro-benzyloxymethyl)-2-oxo-ethyl]-2-methyl-propionamide | CHEMBL325062
TypeSmall organic molecule
Emp. Form.C29H32F5N5O4
Mol. Mass.609.5875
SMILESCC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1 |t:25|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: