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TargetADAM17
LigandBDBM26526
Substrate/Competitorn/a
Meas. Tech.ChEMBL_212588
Ki 0.560000±n/a nM
Citation Duan JJChen LWasserman ZRLu ZLiu RQCovington MBQian MHardman KDMagolda RLNewton RCChrist DDWexler RRDecicco CP Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. J Med Chem 45:4954-7 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
ADAM17
Name:ADAM17
Synonyms:A disintegrin and metalloproteinase domain 17 | ADAM 17 | Snake venom-like protease | TNF-alpha-Converting Enzyme
Type:Metalloprotease
Mol. Mass.:12197.99
Organism:Sus scrofa (pig)
Description:Partially purified TACE was obtained from porcine spleen.
Residue:112
Sequence:
MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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  Blast E-value cutoff:
BDBM26526
n/a
NameBDBM26526
Synonyms:(2R)-N-hydroxy-2-[(3S)-3-methyl-3-{4-[(2-methylquinolin-4-yl)methoxy]phenyl}-2-oxopyrrolidin-1-yl]propanamide | BMCL181958 Compound 1 | CHEMBL148169 | IK682
TypeSmall organic molecule
Emp. Form.C25H27N3O4
Mol. Mass.433.4996
SMILESC[C@@H](N1CC[C@](C)(C1=O)c1ccc(OCc2cc(C)nc3ccccc23)cc1)C(=O)NO |r|
Structure
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