Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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Ligand | BDBM50120691 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_212588 (CHEMBL811890) |
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IC50 | 185±n/a nM |
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Citation | Duan, JJ; Chen, L; Wasserman, ZR; Lu, Z; Liu, RQ; Covington, MB; Qian, M; Hardman, KD; Magolda, RL; Newton, RC; Christ, DD; Wexler, RR; Decicco, CP Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships. J Med Chem45:4954-7 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 17 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
Synonyms: | A disintegrin and metalloproteinase domain 17 | ADA17_PIG | ADAM 17 | ADAM17 | Snake venom-like protease | TACE | TNF-alpha-Converting Enzyme |
Type: | Metalloprotease |
Mol. Mass.: | 12197.99 |
Organism: | Sus scrofa (pig) |
Description: | Partially purified TACE was obtained from porcine spleen. |
Residue: | 112 |
Sequence: | MLREQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPIGK
KNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNE
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BDBM50120691 |
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n/a |
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Name | BDBM50120691 |
Synonyms: | (R)-N-hydroxy-2-((S)-3-methyl-2-oxo-3-(4-phenoxyphenyl)pyrrolidin-1-yl)propanamide | CHEMBL144049 | N-Hydroxy-2-[3-methyl-2-oxo-3-(4-phenoxy-phenyl)-pyrrolidin-1-yl]-propionamide |
Type | Small organic molecule |
Emp. Form. | C20H22N2O4 |
Mol. Mass. | 354.3997 |
SMILES | C[C@@H](N1CC[C@](C)(C1=O)c1ccc(Oc2ccccc2)cc1)C(=O)NO |r| |
Structure |
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