Reaction Details | |||
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Target | Gonadotropin-releasing hormone receptor | ||
Ligand | BDBM50121089 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_71598 | ||
Ki | 66±n/a nM | ||
Citation | Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett12:3467-70 (2002) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gonadotropin-releasing hormone receptor | |||
Name: | Gonadotropin-releasing hormone receptor | ||
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
Type: | Enzyme | ||
Mol. Mass.: | 37749.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30968 | ||
Residue: | 328 | ||
Sequence: |
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BDBM50121089 | |||
n/a | |||
Name | BDBM50121089 | ||
Synonyms: | 5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carboxylic acid {4-[(2,2,2-trifluoro-acetylamino)-methyl]-cyclohexylmethyl}-amide | CHEMBL332923 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H41F3N2O3 | ||
Mol. Mass. | 546.664 | ||
SMILES | Cc1cc2c(cc1Cc1ccc(o1)C(=O)NCC1CCC(CNC(=O)C(F)(F)F)CC1)C(C)(C)CCC2(C)C |(4.72,-8.31,;3.37,-7.54,;2.04,-8.29,;.71,-7.54,;.71,-6,;2.04,-5.23,;3.37,-6,;4.72,-5.23,;4.72,-3.69,;5.88,-2.64,;5.26,-1.26,;3.72,-1.41,;3.39,-2.92,;2.71,-.24,;1.2,-.54,;3.2,1.21,;2.19,2.37,;.68,2.07,;-.33,3.24,;-1.84,2.96,;-2.33,1.49,;-3.85,1.17,;-4.87,2.33,;-4.38,3.77,;-2.89,4.08,;-5.41,4.94,;-6.42,6.08,;-6.55,3.91,;-4.25,5.94,;-1.33,.32,;.17,.62,;-.62,-5.23,;-1.96,-4.46,;.71,-4.46,;-1.96,-6,;-1.96,-7.54,;-.62,-8.29,;.47,-9.39,;-2.12,-8.71,)| | ||
Structure |