Reaction Details | |||
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Target | Gonadotropin-releasing hormone receptor | ||
Ligand | BDBM50121099 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEBML_71598 | ||
Ki | 24±n/a nM | ||
Citation | Luthin, DR; Hong, Y; Pathak, VP; Paderes, G; Nared-Hood, KD; Castro, MA; Vazir, H; Li, H; Tompkins, E; Christie, L; May, JM; Anderson, MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett12:3467-70 (2002) [PubMed] | ||
More Info.: | Get all data from this article, Assay Method | ||
Gonadotropin-releasing hormone receptor | |||
Name: | Gonadotropin-releasing hormone receptor | ||
Synonyms: | GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH) | ||
Type: | Enzyme | ||
Mol. Mass.: | 37749.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P30968 | ||
Residue: | 328 | ||
Sequence: |
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BDBM50121099 | |||
n/a | |||
Name | BDBM50121099 | ||
Synonyms: | 4-({[5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carbonyl]-amino}-methyl)-cyclohexanecarboxylic acid methyl ester | CHEMBL331277 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H41NO4 | ||
Mol. Mass. | 479.6508 | ||
SMILES | COC(=O)[C@H]1CC[C@H](CNC(=O)c2ccc(Cc3cc4c(cc3C)C(C)(C)CCC4(C)C)o2)CC1 |wU:4.3,wD:7.7,(3.41,-.35,;4.92,-.05,;5.93,-1.2,;5.44,-2.66,;7.44,-.89,;7.95,.58,;9.45,.86,;10.46,-.29,;11.96,,;12.98,-1.17,;12.48,-2.61,;10.98,-2.91,;13.5,-3.78,;15.03,-3.62,;15.65,-5.01,;14.5,-6.04,;14.5,-7.58,;13.15,-8.35,;11.82,-7.58,;10.49,-8.35,;10.49,-9.89,;11.82,-10.66,;13.15,-9.89,;14.5,-10.67,;9.16,-10.66,;10.25,-11.75,;7.67,-11.07,;7.82,-9.89,;7.82,-8.35,;9.16,-7.58,;10.5,-6.81,;7.82,-6.81,;13.18,-5.27,;9.96,-1.75,;8.44,-2.05,)| | ||
Structure |