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TargetGonadotropin releasing hormone 1 (GnRHR1)
LigandBDBM50121087
Substrate/Competitorn/a
Meas. Tech.ChEBML_71598
Ki 24±n/a nM
Citation Luthin DRHong YPathak VPPaderes GNared-Hood KDCastro MAVazir HLi HTompkins EChristie LMay JMAnderson MB The discovery of novel small molecule non-peptide gonadotropin releasing hormone (GnRH) receptor antagonists. Bioorg Med Chem Lett 12:3467-70 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Gonadotropin releasing hormone 1 (GnRHR1)
Name:Gonadotropin-releasing hormone receptor
Synonyms:GnRH receptor | GnRH-R | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:Enzyme
Mol. Mass.:37749.45
Organism:Homo sapiens (Human)
Description:P30968
Residue:328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKL
QKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRM
IHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTR
VLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRL
SDPVNHFFFLFAFLNPCFDPLIYGYFSL
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  Blast E-value cutoff:
BDBM50121087
n/a
NameBDBM50121087
Synonyms:5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-ylmethyl)-furan-2-carboxylic acid (4-{[(2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-amino]-methyl}-cyclohexylmethyl)-amide | CHEMBL325747
TypeSmall organic molecule
Emp. Form.C34H46N4O4
Mol. Mass.574.7534
SMILESCc1cc2c(cc1Cc1ccc(o1)C(=O)NCC1CCC(CNCc3cc(=O)[nH]c(=O)[nH]3)CC1)C(C)(C)CCC2(C)C |(5.32,-14.61,;3.97,-13.84,;2.66,-14.61,;1.33,-13.84,;1.33,-12.3,;2.64,-11.53,;3.97,-12.3,;5.3,-11.51,;6.65,-12.28,;6.67,-13.82,;9.33,-13.77,;9.29,-12.23,;7.96,-11.49,;10.62,-11.44,;10.6,-9.9,;11.97,-12.19,;13.28,-11.39,;14.64,-12.14,;14.65,-13.7,;15.99,-14.44,;17.32,-13.66,;18.67,-14.4,;19.98,-13.61,;21.33,-14.37,;22.66,-13.59,;23.99,-14.33,;25.32,-13.56,;26.65,-14.31,;25.3,-12.02,;23.95,-11.25,;23.92,-9.71,;22.62,-12.05,;17.3,-12.09,;15.94,-11.35,;,-11.53,;-1.35,-10.76,;1.33,-10.74,;-1.32,-12.3,;-1.32,-13.84,;,-14.61,;1.33,-15.38,;-1.35,-15.36,)|
Structure
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