Reaction Details |
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Target | Muscarinic acetylcholine receptor M2 |
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Ligand | BDBM50121125 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_140179 |
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Ki | 0.680000±n/a nM |
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Citation | Boyle, CD; Vice, SF; Campion, J; Chackalamannil, S; Lankin, CM; McCombie, SW; Billard, W; Binch, H; Crosby, G; Williams, MC; Coffin, VL; Cox, KA; Grotz, DE; Duffy, RA; Ruperto, V; Lachowicz, JE Enhancement of pharmacokinetic properties and in vivo efficacy of benzylidene ketal M(2) muscarinic receptor antagonists via benzamide modification. Bioorg Med Chem Lett12:3479-82 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M2 |
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Name: | Muscarinic acetylcholine receptor M2 |
Synonyms: | ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51555.53 |
Organism: | RAT |
Description: | P10980 |
Residue: | 466 |
Sequence: | MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRI
VKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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BDBM50121125 |
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n/a |
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Name | BDBM50121125 |
Synonyms: | (2-Amino-5-fluoro-phenyl)-(4-{2-[4-(4-methoxy-benzenesulfonyl)-phenyl]-[1,3]dioxolan-2-yl}-[1,4']bipiperidinyl-1'-yl)-methanone | CHEMBL117414 |
Type | Small organic molecule |
Emp. Form. | C33H38FN3O6S |
Mol. Mass. | 623.735 |
SMILES | COc1ccc(cc1)S(=O)(=O)c1ccc(cc1)C1(OCCO1)C1CCN(CC1)C1CCN(CC1)C(=O)c1cc(F)ccc1N |
Structure |
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