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TargetCathepsin L1
LigandBDBM50121295
Substrate/Competitorn/a
Meas. Tech.ChEMBL_48503
Ki 240±n/a nM
Citation Chowdhury SFSivaraman JWang JDevanathan GLachance PQi HMénard RLefebvre JKonishi YCygler MSulea TPurisima EO Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides. J Med Chem 45:5321-9 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50121295
n/a
NameBDBM50121295
Synonyms:2-[2-(2-Biphenyl-4-yl-acetylamino)-3-methylsulfanyl-propionylamino]-5-guanidino-pentanoic acid (3-methylsulfanyl-1-phenethylcarbamoyl-propyl)-amide | CHEMBL118293
TypeSmall organic molecule
Emp. Form.C37H49N7O4S2
Mol. Mass.719.959
SMILESCSCCC(NC(=O)C(CCCNC(N)=N)NC(=O)C(CSC)NC(=O)Cc1ccc(cc1)-c1ccccc1)C(=O)NCCc1ccccc1
Structure
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