| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM50121291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48503 (CHEMBL660652) |
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| Ki | 19±n/a nM |
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| Citation |  Chowdhury, SF; Sivaraman, J; Wang, J; Devanathan, G; Lachance, P; Qi, H; Ménard, R; Lefebvre, J; Konishi, Y; Cygler, M; Sulea, T; Purisima, EO Design of noncovalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides. J Med Chem45:5321-9 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50121291 |
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| n/a |
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| Name | BDBM50121291 |
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| Synonyms: | 2-[2-(2-Biphenyl-4-yl-acetylamino)-3-methylsulfanyl-propionylamino]-5-guanidino-pentanoic acid [1-(1-phenethylcarbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethyl]-amide | CHEMBL415539 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H58N8O5S |
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| Mol. Mass. | 883.111 |
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| SMILES | CSCC(NC(=O)Cc1ccc(cc1)-c1ccccc1)C(=O)N[C@H](CCCNC(N)=N)C(=O)NC(Cc1ccccc1)C(=O)NC(Cc1ccccc1)C(=O)NCCc1ccccc1 |
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| Structure | 
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