Ki Summary

Reaction Details

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Target

Peptide deformylase, mitochondrial

Ligand

BDBM50104501

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_154177 (CHEMBL762381)

IC50

7±n/a nM

Citation

Smith, HK; Beckett, RP; Clements, JM; Doel, S; East, SP; Launchbury, SB; Pratt, LM; Spavold, ZM; Thomas, W; Todd, RS; Whittaker, M Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the metal binding group. Bioorg Med Chem Lett12:3595-9 (2002) [PubMed]

More Info.:

Get all data from this article, Assay Method

Peptide deformylase, mitochondrial

Name:

Peptide deformylase, mitochondrial

Synonyms:

Type:

PROTEIN

Mol. Mass.:

27023.25

Organism:

Homo sapiens (Human)

Description:

ChEMBL_154318

Residue:

243

Sequence:

MARLWGALSLWPLWAAVPWGGAAAVGVRACSSTAAPDGVEGPALRRSYWRHLRRLVLGPP
EPPFSHVCQVGDPVLRGVAAPVERAQLGGPELQRLTQRLVQVMRRRRCVGLSAPQLGVPR
QVLALELPEALCRECPPRQRALRQMEPFPLRVFVNPSLRVLDSRLVTFPEGCESVAGFLA
CVPRFQAVQISGLDPNGEQVVWQASGWAARIIQHEMDHLQGCLFIDKMDSRTFTNVYWMK
VND

BDBM50104501

n/a

Name

BDBM50104501

Synonyms:

(R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amide | (R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid ((S)-1-dimethylcarbamoyl-2-methyl-2-methyl-propyl)-amide | (R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid (1-dimethylcarbamoyl-2,2-dimethyl-propyl)-amide | (R)-2-[(Formyl-hydroxy-amino)-methyl]-hexanoic acid [1-((S)-dimethyl-carbamoyl)-2,2-dimethyl-propyl]-amide | 2-[(FORMYL-HYDROXY-AMINO)-METHYL]-HEXANOIC ACID (1-DIMETHYLCARBAMOYL-2,2-DIMETHYL-PROPYL)-AMIDE | BB-3497 | CHEMBL431210

Type

Small organic molecule

Emp. Form.

C16H31N3O4

Mol. Mass.

329.435

SMILES

CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)N(C)C)C(C)(C)C

Structure