Reaction Details |
| Report a problem with these data |
Target | Cathepsin S |
---|
Ligand | BDBM50121572 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_48672 (CHEMBL658343) |
---|
IC50 | 17±n/a nM |
---|
Citation | Ward, YD; Thomson, DS; Frye, LL; Cywin, CL; Morwick, T; Emmanuel, MJ; Zindell, R; McNeil, D; Bekkali, Y; Girardot, M; Hrapchak, M; DeTuri, M; Crane, K; White, D; Pav, S; Wang, Y; Hao, MH; Grygon, CA; Labadia, ME; Freeman, DM; Davidson, W; Hopkins, JL; Brown, ML; Spero, DM; Giradot, M Design and synthesis of dipeptide nitriles as reversible and potent Cathepsin S inhibitors. J Med Chem45:5471-82 (2002) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cathepsin S |
---|
Name: | Cathepsin S |
Synonyms: | CATS_HUMAN | CTSS | Cathepsin S (Cat S) | cathepsin S preproprotein |
Type: | Protein |
Mol. Mass.: | 37507.38 |
Organism: | Homo sapiens (Human) |
Description: | P25774 |
Residue: | 331 |
Sequence: | MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVM
LHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVD
WREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGC
NGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKE
AVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSW
GHNFGEEGYIRMARNKGNHCGIASFPSYPEI
|
|
|
BDBM50121572 |
---|
n/a |
---|
Name | BDBM50121572 |
Synonyms: | CHEMBL150358 | Morpholine-4-carboxylic acid {1-[(cyano-dimethyl-methyl)-carbamoyl]-2-cyclohexyl-ethyl}-amide |
Type | Small organic molecule |
Emp. Form. | C18H30N4O3 |
Mol. Mass. | 350.4558 |
SMILES | CC(C)(NC(=O)[C@H](CC1CCCCC1)NC(=O)N1CCOCC1)C#N |
Structure |
|