| Reaction Details |
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 | Report a problem with these data |
| Target | Mu-type opioid receptor |
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| Ligand | BDBM50121638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_148854 (CHEMBL756650) |
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| Ki | 0.76±n/a nM |
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| Citation |  Bryant, SD; George, C; Flippen-Anderson, JL; Deschamps, JR; Salvadori, S; Balboni, G; Guerrini, R; Lazarus, LH Crystal structures of dipeptides containing the Dmt-Tic pharmacophore. J Med Chem45:5506-13 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Mu-type opioid receptor |
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| Name: | Mu-type opioid receptor |
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| Synonyms: | MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44503.11 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor. |
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| Residue: | 398 |
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| Sequence: | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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| BDBM50121638 |
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| n/a |
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| Name | BDBM50121638 |
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| Synonyms: | 1-[3-(Adamantan-1-ylamino)-3,4-dihydro-1H-isoquinolin-2-yl]-2-amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propan-1-one | CHEMBL422855 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H39N3O2 |
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| Mol. Mass. | 473.6496 |
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| SMILES | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2CC1NC12CC3CC(CC(C3)C1)C2 |TLB:28:29:33:27.26.32,THB:28:27:33:29.34.30,30:29:26:31.33.32,30:31:26:29.34.28| |
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| Structure | 
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