| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucagon receptor |
|---|
| Ligand | BDBM50122124 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_72875 (CHEMBL684126) |
|---|
| IC50 | 6.6±n/a nM |
|---|
| Citation |  Madsen, P; Ling, A; Plewe, M; Sams, CK; Knudsen, LB; Sidelmann, UG; Ynddal, L; Brand, CL; Andersen, B; Murphy, D; Teng, M; Truesdale, L; Kiel, D; May, J; Kuki, A; Shi, S; Johnson, MD; Teston, KA; Feng, J; Lakis, J; Anderes, K; Gregor, V; Lau, J Optimization of alkylidene hydrazide based human glucagon receptor antagonists. Discovery of the highly potent and orally available 3-cyano-4-hydroxybenzoic acid [1-(2,3,5,6-tetramethylbenzyl)-1H-indol-4-ylmethylene]hydrazide. J Med Chem45:5755-75 (2002) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucagon receptor |
|---|
| Name: | Glucagon receptor |
|---|
| Synonyms: | GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54026.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P47871 |
|---|
| Residue: | 477 |
|---|
| Sequence: | MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
|
|
|
|---|
| BDBM50122124 |
|---|
| n/a |
|---|
| Name | BDBM50122124 |
|---|
| Synonyms: | 3-Chloro-4-hydroxy-benzoic acid (4-{2-[4-(4-bromo-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-oxo-ethoxy}-naphthalen-1-ylmethylene)-hydrazide | CHEMBL152207 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H25BrClN3O4 |
|---|
| Mol. Mass. | 618.905 |
|---|
| SMILES | Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCC(=O)N2CCC(=CC2)c2ccc(Br)cc2)c2ccccc12 |c:25| |
|---|
| Structure | 
|
|---|
Search and Browse
