| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50122771 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_210622 (CHEMBL811739) |
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| IC50 | 21±n/a nM |
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| Citation |  Cole, C; Reigan, P; Gbaj, A; Edwards, PN; Douglas, KT; Stratford, IJ; Freeman, S; Jaffar, M Potential tumor-selective nitroimidazolylmethyluracil prodrug derivatives: inhibitors of the angiogenic enzyme thymidine phosphorylase. J Med Chem46:207-9 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | ECGF1 | Gliostatin | PD-ECGF | Platelet-derived endothelial cell growth factor | TP | TYMP | TYPH_HUMAN | TdRPase | Thymidine Phosphorylase (TP) | Thymidine phosphorylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 49948.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319). |
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| Residue: | 482 |
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| Sequence: | MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAA
VVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGG
VGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQA
GCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAA
VFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPP
DLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARAL
CSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVG
AELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPP
QQ
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| BDBM50122771 |
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| n/a |
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| Name | BDBM50122771 |
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| Synonyms: | 2-Amino-1-(5-chloro-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-ylmethyl)-3H-imidazol-1-ium; chloride | CHEMBL193667 | CHEMBL66531 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H9ClN5O2 |
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| Mol. Mass. | 242.642 |
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| SMILES | Nc1[nH+]ccn1Cc1[nH]c(=O)[nH]c(=O)c1Cl |
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| Structure | 
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