| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
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| Ligand | BDBM50122916 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_124648 (CHEMBL731909) |
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| IC50 | 28±n/a nM |
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| Citation |  Colletti, SL; Frie, JL; Dixon, EC; Singh, SB; Choi, BK; Scapin, G; Fitzgerald, CE; Kumar, S; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Porter, G; Samuel, K; Schmatz, DM; Schwartz, CD; Shoop, WL; Thompson, CM; Thompson, JE; Wang, R; Woods, A; Zaller, DM; Doherty, JB Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones. J Med Chem46:349-52 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 11 |
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| Name: | Mitogen-activated protein kinase 11 |
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| Synonyms: | MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B |
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| Type: | Enzyme |
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| Mol. Mass.: | 41390.66 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Q9WUI1 |
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| Residue: | 364 |
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| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ
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| BDBM50122916 |
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| n/a |
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| Name | BDBM50122916 |
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| Synonyms: | 6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2-o-tolyl-2H-pyridazin-3-one | CHEMBL118651 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16ClFN4O |
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| Mol. Mass. | 430.861 |
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| SMILES | Cc1ccccc1-n1nc(ccc1=O)-c1c(nc2ccccn12)-c1ccc(F)cc1Cl |
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| Structure | 
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