Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase 11

Ligand

BDBM50122910

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_124648 (CHEMBL731909)

IC50

153±n/a nM

Citation

Colletti, SL; Frie, JL; Dixon, EC; Singh, SB; Choi, BK; Scapin, G; Fitzgerald, CE; Kumar, S; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Porter, G; Samuel, K; Schmatz, DM; Schwartz, CD; Shoop, WL; Thompson, CM; Thompson, JE; Wang, R; Woods, A; Zaller, DM; Doherty, JB Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones. J Med Chem46:349-52 (2003) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 11

Name:

Mitogen-activated protein kinase 11

Synonyms:

Type:

Enzyme

Mol. Mass.:

41390.66

Organism:

Mus musculus (mouse)

Description:

Q9WUI1

Residue:

364

Sequence:

MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ

BDBM50122910

n/a

Name

BDBM50122910

Synonyms:

2-(2,6-Dichloro-phenyl)-6-[2-(4-fluoro-phenyl)-imidazo[1,2-a]pyridin-3-yl]-2H-pyridazin-3-one | 2-(2,6-dichlorophenyl)-6-(2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl)pyridazin-3(2H)-one | CHEMBL117109

Type

Small organic molecule

Emp. Form.

C23H13Cl2FN4O

Mol. Mass.

451.28

SMILES

Fc1ccc(cc1)-c1nc2ccccn2c1-c1ccc(=O)n(n1)-c1c(Cl)cccc1Cl |(-4.28,-10.03,;-3.48,-8.71,;-4.22,-7.36,;-3.43,-6.05,;-1.89,-6.08,;-1.14,-7.42,;-1.94,-8.74,;-1.1,-4.75,;.4,-5.08,;1.17,-3.75,;2.67,-3.44,;3.16,-1.98,;2.13,-.83,;.62,-1.14,;.15,-2.6,;-1.27,-3.22,;-2.6,-2.44,;-3.93,-3.21,;-5.26,-2.43,;-5.26,-.9,;-6.59,-.13,;-3.92,-.13,;-2.59,-.9,;-3.92,1.41,;-5.25,2.18,;-6.59,1.41,;-5.25,3.72,;-3.92,4.49,;-2.59,3.73,;-2.58,2.18,;-1.25,1.41,)|

Structure