| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 11 |
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| Ligand | BDBM50122921 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_124648 (CHEMBL731909) |
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| IC50 | 355±n/a nM |
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| Citation |  Colletti, SL; Frie, JL; Dixon, EC; Singh, SB; Choi, BK; Scapin, G; Fitzgerald, CE; Kumar, S; Nichols, EA; O'Keefe, SJ; O'Neill, EA; Porter, G; Samuel, K; Schmatz, DM; Schwartz, CD; Shoop, WL; Thompson, CM; Thompson, JE; Wang, R; Woods, A; Zaller, DM; Doherty, JB Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones. J Med Chem46:349-52 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 11 |
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| Name: | Mitogen-activated protein kinase 11 |
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| Synonyms: | MAP Kinase p38 beta | MK11_MOUSE | Mapk11 | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | Prkm11 | p38B |
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| Type: | Enzyme |
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| Mol. Mass.: | 41390.66 |
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| Organism: | Mus musculus (mouse) |
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| Description: | Q9WUI1 |
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| Residue: | 364 |
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| Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGNDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSVFHGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPDDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPLEPSQLPGTH
EIEQ
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| BDBM50122921 |
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| n/a |
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| Name | BDBM50122921 |
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| Synonyms: | 2-(2-Chloro-phenyl)-6-[2-(3-trifluoromethyl-phenyl)-imidazo[1,2-a]pyridin-3-yl]-4,5-dihydro-2H-pyridazin-3-one | 2-(2-chlorophenyl)-6-(2-(3-(trifluoromethyl)phenyl)imidazo[1,2-a]pyridin-3-yl)-4,5-dihydropyridazin-3(2H)-one | CHEMBL119675 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H16ClF3N4O |
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| Mol. Mass. | 468.858 |
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| SMILES | FC(F)(F)c1cccc(c1)-c1nc2ccccn2c1C1=NN(C(=O)CC1)c1ccccc1Cl |t:22| |
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| Structure | 
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