Reaction Details |
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Target | Thyroid hormone receptor beta |
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Ligand | BDBM50123051 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_210497 |
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Ki | 10000±n/a nM |
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Citation | Dow, RL; Schneider, SR; Paight, ES; Hank, RF; Chiang, P; Cornelius, P; Lee, E; Newsome, WP; Swick, AG; Spitzer, J; Hargrove, DM; Patterson, TA; Pandit, J; Chrunyk, BA; LeMotte, PK; Danley, DE; Rosner, MH; Ammirati, MJ; Simons, SP; Schulte, GK; Tate, BF; DaSilva-Jardine, P Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett13:379-82 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid hormone receptor beta |
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Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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BDBM50123051 |
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n/a |
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Name | BDBM50123051 |
Synonyms: | 1-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-phenyl]-tetrahydro-pyrimidin-2-one | CHEMBL124844 |
Type | Small organic molecule |
Emp. Form. | C21H26N2O3 |
Mol. Mass. | 354.4427 |
SMILES | CC(C)c1cc(Oc2c(C)cc(cc2C)N2CCCNC2=O)ccc1O |
Structure |
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