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TargetThyroid hormone receptor beta
LigandBDBM50123051
Substrate/Competitorn/a
Meas. Tech.ChEBML_210497
Ki 10000±n/a nM
Citation Dow, RLSchneider, SRPaight, ESHank, RFChiang, PCornelius, PLee, ENewsome, WPSwick, AGSpitzer, JHargrove, DMPatterson, TAPandit, JChrunyk, BALeMotte, PKDanley, DERosner, MHAmmirati, MJSimons, SPSchulte, GKTate, BFDaSilva-Jardine, P Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett13:379-82 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Thyroid hormone receptor beta
Name:Thyroid hormone receptor beta
Synonyms:ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta
Type:Receptor
Mol. Mass.:52793.62
Organism:Homo sapiens (Human)
Description:Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1.
Residue:461
Sequence:
MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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  Blast E-value cutoff:
BDBM50123051
n/a
NameBDBM50123051
Synonyms:1-[4-(4-Hydroxy-3-isopropyl-phenoxy)-3,5-dimethyl-phenyl]-tetrahydro-pyrimidin-2-one | CHEMBL124844
TypeSmall organic molecule
Emp. Form.C21H26N2O3
Mol. Mass.354.4427
SMILESCC(C)c1cc(Oc2c(C)cc(cc2C)N2CCCNC2=O)ccc1O
Structure
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