| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thyroid hormone receptor beta |
|---|
| Ligand | BDBM50123050 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_210497 |
|---|
| Ki | 0.640000±n/a nM |
|---|
| Citation |  Dow, RL; Schneider, SR; Paight, ES; Hank, RF; Chiang, P; Cornelius, P; Lee, E; Newsome, WP; Swick, AG; Spitzer, J; Hargrove, DM; Patterson, TA; Pandit, J; Chrunyk, BA; LeMotte, PK; Danley, DE; Rosner, MH; Ammirati, MJ; Simons, SP; Schulte, GK; Tate, BF; DaSilva-Jardine, P Discovery of a novel series of 6-azauracil-based thyroid hormone receptor ligands: potent, TR beta subtype-selective thyromimetics. Bioorg Med Chem Lett13:379-82 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thyroid hormone receptor beta |
|---|
| Name: | Thyroid hormone receptor beta |
|---|
| Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
|---|
| Type: | Receptor |
|---|
| Mol. Mass.: | 52793.62 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
|---|
| Residue: | 461 |
|---|
| Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
|
|
|
|---|
| BDBM50123050 |
|---|
| n/a |
|---|
| Name | BDBM50123050 |
|---|
| Synonyms: | CHEMBL124318 | N-Cyclobutyl-5-[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-3H-[1,2,4]triazin-2-yl)-phenoxy]-2-hydroxy-benzamide | N-cyclobutyl-5-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenoxy)-2-hydroxybenzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H16Cl2N4O5 |
|---|
| Mol. Mass. | 463.271 |
|---|
| SMILES | Oc1ccc(Oc2c(Cl)cc(cc2Cl)-n2ncc(=O)[nH]c2=O)cc1C(=O)NC1CCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
