| Reaction Details |
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 | Report a problem with these data |
| Target | Tumor necrosis factor receptor superfamily member 1A |
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| Ligand | BDBM50123291 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_212214 |
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| IC50 | 140±n/a nM |
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| Citation |  Voss, ME; Carter, PH; Tebben, AJ; Scherle, PA; Brown, GD; Thompson, LA; Xu, M; Lo, YC; Yang, G; Liu, RQ; Strzemienski, P; Everlof, JG; Trzaskos, JM; Decicco, CP Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists. Bioorg Med Chem Lett13:533-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Tumor necrosis factor receptor superfamily member 1A |
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| Name: | Tumor necrosis factor receptor superfamily member 1A |
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| Synonyms: | CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50495.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1509419 |
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| Residue: | 455 |
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| Sequence: | MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
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| BDBM50123291 |
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| n/a |
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| Name | BDBM50123291 |
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| Synonyms: | 3-Ethyl-5-[1-[5-(2-methyl-5-trifluoromethyl-2H-pyrazol-3-yl)-thiophen-2-yl]-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one | CHEMBL357092 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12F3N3OS3 |
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| Mol. Mass. | 403.465 |
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| SMILES | CCN1C(=S)S\C(=C/c2ccc(s2)-c2cc(nn2C)C(F)(F)F)C1=O |
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| Structure | 
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