Reaction Details |
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Target | Tumor necrosis factor receptor superfamily member 1A |
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Ligand | BDBM50123298 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_212214 |
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IC50 | 310±n/a nM |
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Citation | Voss, ME; Carter, PH; Tebben, AJ; Scherle, PA; Brown, GD; Thompson, LA; Xu, M; Lo, YC; Yang, G; Liu, RQ; Strzemienski, P; Everlof, JG; Trzaskos, JM; Decicco, CP Both 5-arylidene-2-thioxodihydropyrimidine-4,6(1H,5H)-diones and 3-thioxo-2,3-dihydro-1H-imidazo[1,5-a]indol-1-ones are light-dependent tumor necrosis factor-alpha antagonists. Bioorg Med Chem Lett13:533-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Tumor necrosis factor receptor superfamily member 1A |
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Name: | Tumor necrosis factor receptor superfamily member 1A |
Synonyms: | CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60 |
Type: | PROTEIN |
Mol. Mass.: | 50495.39 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1509419 |
Residue: | 455 |
Sequence: | MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
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BDBM50123298 |
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n/a |
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Name | BDBM50123298 |
Synonyms: | 2-Ethyl-8-methoxy-6-(pyridin-2-ylmethoxy)-3-thioxo-2,3-dihydro-imidazo[1,5-a]indol-1-one | CHEMBL423208 |
Type | Small organic molecule |
Emp. Form. | C19H17N3O3S |
Mol. Mass. | 367.422 |
SMILES | CCN1C(=O)c2cc3c(OC)cc(OCc4ccccn4)cc3n2C1=S |
Structure |
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