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TargetTaq polymerase 1
LigandBDBM50123623
Substrate/Competitorn/a
Meas. Tech.ChEMBL_209728
IC50 60±n/a nM
Citation Kim MYDuan WGleason-Guzman MHurley LH Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes. J Med Chem 46:571-83 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Taq polymerase 1
Name:Taq polymerase 1
Synonyms:DNA polymerase I, thermostable
Type:PROTEIN
Mol. Mass.:93906.95
Organism:Thermus aquaticus
Description:ChEMBL_1289218
Residue:832
Sequence:
MRGMLPLFEPKGRVLLVDGHHLAYRTFHALKGLTTSRGEPVQAVYGFAKSLLKALKEDGD
AVIVVFDAKAPSFRHEAYGGYKAGRAPTPEDFPRQLALIKELVDLLGLARLEVPGYEADD
VLASLAKKAEKEGYEVRILTADKDLYQLLSDRIHVLHPEGYLITPAWLWEKYGLRPDQWA
DYRALTGDESDNLPGVKGIGEKTARKLLEEWGSLEALLKNLDRLKPAIREKILAHMDDLK
LSWDLAKVRTDLPLEVDFAKRREPDRERLRAFLERLEFGSLLHEFGLLESPKALEEAPWP
PPEGAFVGFVLSRKEPMWADLLALAAARGGRVHRAPEPYKALRDLKEARGLLAKDLSVLA
LREGLGLPPGDDPMLLAYLLDPSNTTPEGVARRYGGEWTEEAGERAALSERLFANLWGRL
EGEERLLWLYREVERPLSAVLAHMEATGVRLDVAYLRALSLEVAEEIARLEAEVFRLAGH
PFNLNSRDQLERVLFDELGLPAIGKTEKTGKRSTSAAVLEALREAHPIVEKILQYRELTK
LKSTYIDPLPDLIHPRTGRLHTRFNQTATATGRLSSSDPNLQNIPVRTPLGQRIRRAFIA
EEGWLLVALDYSQIELRVLAHLSGDENLIRVFQEGRDIHTETASWMFGVPREAVDPLMRR
AAKTINFGVLYGMSAHRLSQELAIPYEEAQAFIERYFQSFPKVRAWIEKTLEEGRRRGYV
ETLFGRRRYVPDLEARVKSVREAAERMAFNMPVQGTAADLMKLAMVKLFPRLEEMGARML
LQVHDELVLEAPKERAEAVARLAKEVMEGVYPLAVPLEVEVGIGEDWLSAKE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50123623
n/a
NameBDBM50123623
Synonyms:(R)-13-(3-aminopyrrolidin-1-yl)-12-fluoro-10-oxo-10H-naphtho[1,2-c]pyrido[3,2,1-kl]phenoxazine-9-carboxylic acid | 13-[3-amino-(3R)-tetrahydro-1H-1-pyrrolyl]-12-fluoro-10-oxo-10H-naphtho[1,2-c]pyrido[3,2,1-kl]phenoxazine-9-carboxylic acid | CHEMBL346068
TypeSmall organic molecule
Emp. Form.C28H20FN3O4
Mol. Mass.481.4745
SMILESN[C@@H]1CCN(C1)c1c(F)cc2c3c1oc1c4ccc5ccccc5c4ccc1n3cc(C(O)=O)c2=O
Structure
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