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TargetProtein phosphatase 3 catalytic subunit alpha
LigandBDBM50123744
Substrate/Competitorn/a
Meas. Tech.ChEMBL_42588 (CHEMBL653182)
IC50 636±n/a nM
Citation Lazarova, TChen, JSHamann, BKang, JMHomuth-Trombino, DHan, FHoffmann, EMcClure, CEckstein, JOr, YS Synthesis and biological evaluation of novel cyclosporin a analogues: potential soft drugs for the treatment of autoimmune diseases. J Med Chem46:674-6 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Protein phosphatase 3 catalytic subunit alpha
Name:Protein phosphatase 3 catalytic subunit alpha
Synonyms:CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin
Type:Enzyme Catalytic Domain
Mol. Mass.:58681.14
Organism:Homo sapiens (Human)
Description:calcineurin 0 HUMAN::Q08209
Residue:521
Sequence:
MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50123744
n/a
NameBDBM50123744
Synonyms:6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacont-2-yl)-6-hydroxy-5-methyl-hex-2-enoic acid 2-fluoro-ethyl ester | CHEMBL413883
TypeSmall organic molecule
Emp. Form.C64H112FN11O14
Mol. Mass.1278.6378
SMILESCC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C(=O)OCCF)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
Structure
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