Reaction Details |
| Report a problem with these data |
Target | Protein phosphatase 3 catalytic subunit alpha |
---|
Ligand | BDBM50123744 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_42588 (CHEMBL653182) |
---|
IC50 | 636±n/a nM |
---|
Citation | Lazarova, T; Chen, JS; Hamann, B; Kang, JM; Homuth-Trombino, D; Han, F; Hoffmann, E; McClure, C; Eckstein, J; Or, YS Synthesis and biological evaluation of novel cyclosporin a analogues: potential soft drugs for the treatment of autoimmune diseases. J Med Chem46:674-6 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Protein phosphatase 3 catalytic subunit alpha |
---|
Name: | Protein phosphatase 3 catalytic subunit alpha |
Synonyms: | CALNA | CNA | PP2BA_HUMAN | PPP3CA | Serine/threonine protein phosphatase 2B catalytic subunit, alpha isoform | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | calcineurin |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58681.14 |
Organism: | Homo sapiens (Human) |
Description: | calcineurin 0 HUMAN::Q08209 |
Residue: | 521 |
Sequence: | MSEPKAIDPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESV
ALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYV
DRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMD
AFDCLPLAALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFG
NEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFP
SLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEK
VTEMLVNVLNICSDDELGSEEDGFDGATAAARKEVIRNKIRAIGKMARVFSVLREESESV
LTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFSPQHKITSFEEAKGLDRIN
ERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ
|
|
|
BDBM50123744 |
---|
n/a |
---|
Name | BDBM50123744 |
Synonyms: | 6-(5-Ethyl-11,17,26,29-tetraisobutyl-14,32-diisopropyl-1,7,10,16,20,23,25,28,31-nonamethyl-3,6,9,12,15,18,21,24,27,30,33-undecaoxo-1,4,7,10,13,16,19,22,25,28,31undecaaza-cyclotritriacont-2-yl)-6-hydroxy-5-methyl-hex-2-enoic acid 2-fluoro-ethyl ester | CHEMBL413883 |
Type | Small organic molecule |
Emp. Form. | C64H112FN11O14 |
Mol. Mass. | 1278.6378 |
SMILES | CC[C@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C(=O)OCCF)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C |
Structure |
|