Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 1 |
---|
Ligand | BDBM50123957 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_87856 (CHEMBL877713) |
---|
IC50 | 100±n/a nM |
---|
Citation | Bouchain, G; Leit, S; Frechette, S; Khalil, EA; Lavoie, R; Moradei, O; Woo, SH; Fournel, M; Yan, PT; Kalita, A; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Robert, MF; MacLeod, AR; Besterman, JM; Delorme, D Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. J Med Chem46:820-30 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 1 |
---|
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
BDBM50123957 |
---|
n/a |
---|
Name | BDBM50123957 |
Synonyms: | (E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoic acid hydroxyamide | (E)-5-(4-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoic acid hydroxyamide | 5-(4-Benzenesulfonylamino-phenyl)-pent-2-en-4-ynoic acid hydroxyamide | CHEMBL314389 | Oxamflatin |
Type | Small organic molecule |
Emp. Form. | C17H14N2O4S |
Mol. Mass. | 342.369 |
SMILES | ONC(=O)\C=C\C#Cc1ccc(NS(=O)(=O)c2ccccc2)cc1 |
Structure |
|