Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50085027 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_147150 (CHEMBL758175) |
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Ki | 2800±n/a nM |
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Citation | Wentland, MP; Ye, Y; Cioffi, CL; Lou, R; Zhou, Q; Xu, G; Duan, W; Dehnhardt, CM; Sun, X; Cohen, DJ; Bidlack, JM Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines. J Med Chem46:838-49 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50085027 |
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n/a |
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Name | BDBM50085027 |
Synonyms: | (6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-8-morpholin-4-yl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine | 3-Cyclopropylmethyl-6,11-dimethyl-8-morpholin-4-yl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine | CHEMBL55248 |
Type | Small organic molecule |
Emp. Form. | C22H32N2O |
Mol. Mass. | 340.5023 |
SMILES | C[C@H]1C2Cc3ccc(cc3[C@@]1(C)CCN2CC1CC1)N1CCOCC1 |TLB:8:9:1:14.12.13,15:14:1:9.4.3| |
Structure |
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