| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50124474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_65486 |
|---|
| IC50 | 1±n/a nM |
|---|
| Citation |  Bolli, MH; Boss, C; Clozel, M; Fischli, W; Hess, P; Weller, T The use of sulfonylamido pyrimidines incorporating an unsaturated side chain as endothelin receptor antagonists. Bioorg Med Chem Lett13:955-9 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48736.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25101 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
|
|
|---|
| BDBM50124474 |
|---|
| n/a |
|---|
| Name | BDBM50124474 |
|---|
| Synonyms: | CHEMBL94786 | Pyridin-2-yl-carbamic acid 4-[6-(5-isopropyl-pyridine-2-sulfonylamino)-5-(2-methoxy-phenoxy)-2-morpholin-4-yl-pyrimidin-4-yloxy]-but-2-ynyl ester |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H35N7O8S |
|---|
| Mol. Mass. | 689.738 |
|---|
| SMILES | COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cn2)C(C)C)nc(nc1OCC#CCOC(=O)Nc1ccccn1)N1CCOCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
