| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
|---|
| Ligand | BDBM50124566 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_144973 (CHEMBL873910) |
|---|
| Ki | 9±n/a nM |
|---|
| Citation |  Goodman, MM; Chen, P; Plisson, C; Martarello, L; Galt, J; Votaw, JR; Kilts, CD; Malveaux, G; Camp, VM; Shi, B; Ely, TD; Howell, L; McConathy, J; Nemeroff, CB Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. J Med Chem46:925-35 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent noradrenaline transporter |
|---|
| Name: | Sodium-dependent noradrenaline transporter |
|---|
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69337.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23975 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
|
|
|
|---|
| BDBM50124566 |
|---|
| n/a |
|---|
| Name | BDBM50124566 |
|---|
| Synonyms: | (R)-2-((R)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)morpholine | 2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine | 2-[(2-Ethoxy-phenoxy)-phenyl-methyl]-morpholine | 2-[2-ethoxyphenoxy(phenyl)methyl]-1,4-oxazinane | CHEMBL14370 | REBOXETINE | rac-syn-2-((2-ethoxyphenoxy)(phenyl)methyl)morpholine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23NO3 |
|---|
| Mol. Mass. | 313.3908 |
|---|
| SMILES | CCOc1ccccc1OC(C1CNCCO1)c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
