| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glucocorticoid receptor |
|---|
| Ligand | BDBM50107347 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_201612 |
|---|
| EC50 | 48±n/a nM |
|---|
| Citation |  Kym, PR; Kort, ME; Coghlan, MJ; Moore, JL; Tang, R; Ratajczyk, JD; Larson, DP; Elmore, SW; Pratt, JK; Stashko, MA; Falls, HD; Lin, CW; Nakane, M; Miller, L; Tyree, CM; Miner, JN; Jacobson, PB; Wilcox, DM; Nguyen, P; Lane, BC Nonsteroidal selective glucocorticoid modulators: the effect of C-10 substitution on receptor selectivity and functional potency of 5-allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines. J Med Chem46:1016-30 (2003) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glucocorticoid receptor |
|---|
| Name: | Glucocorticoid receptor |
|---|
| Synonyms: | GCR_RAT | Glucocorticoid | Glucocorticoid Receptor (GR) | Glucocorticoid receptor | Grl | Nr3c1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 87556.83 |
|---|
| Organism: | RAT |
|---|
| Description: | Glucocorticoid 0 RAT::P06536 |
|---|
| Residue: | 795 |
|---|
| Sequence: | MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQ
RILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQQPDLSKAVSLSMGLYMGETETKVMG
NDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKT
HSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGSPSKDTNESPWRSDLLI
DENLLSPLAGEDDPFLLEGNTNEDCKPLILPDTKPKIKDTGDTILSSPSSVALPQVKTEK
DDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTAS
LSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRP
DVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRN
DCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVP
AALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIL
GLRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQ
CKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIV
KREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIP
KYSNGNIKKLLFHQK
|
|
|
|---|
| BDBM50107347 |
|---|
| n/a |
|---|
| Name | BDBM50107347 |
|---|
| Synonyms: | (+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | (+/-)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | (-)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | 5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene | 5-allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-f]quinoline | CHEMBL266282 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H25NO2 |
|---|
| Mol. Mass. | 347.4501 |
|---|
| SMILES | COc1cccc2OC(CC=C)c3c(ccc4NC(C)(C)C=C(C)c34)-c12 |t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
