Reaction Details |
| Report a problem with these data |
Target | Methionine--tRNA ligase |
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Ligand | BDBM50124803 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105150 (CHEMBL716780) |
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IC50 | 4±n/a nM |
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Citation | Jarvest, RL; Berge, JM; Brown, MJ; Brown, P; Elder, JS; Forrest, AK; Houge-Frydrych, CS; O'Hanlon, PJ; McNair, DJ; Rittenhouse, S; Sheppard, RJ Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. Bioorg Med Chem Lett13:665-8 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Methionine--tRNA ligase |
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Name: | Methionine--tRNA ligase |
Synonyms: | Methionyl-tRNA synthetase | SYM_ECOLI | metG |
Type: | PROTEIN |
Mol. Mass.: | 76245.79 |
Organism: | Escherichia coli (strain K12) |
Description: | ChEMBL_400681 |
Residue: | 677 |
Sequence: | MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIM
LKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFI
KNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSG
ATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFG
FEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVY
FHSLFWPAMLEGSNFRKPSNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYY
TAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYK
TFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSM
GINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQV
EALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLR
LTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKD
IFLLSPDAGAKPGHQVK
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BDBM50124803 |
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n/a |
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Name | BDBM50124803 |
Synonyms: | 5-Bromo-2-ethoxy-3-{[3-(4-oxo-1,4-dihydro-quinolin-2-ylamino)-propylamino]-methyl}-benzonitrile | CHEMBL159035 |
Type | Small organic molecule |
Emp. Form. | C22H23BrN4O2 |
Mol. Mass. | 455.348 |
SMILES | CCOc1c(CNCCCNc2cc(O)c3ccccc3n2)cc(Br)cc1C#N |
Structure |
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