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TargetMethionine--tRNA ligase
LigandBDBM50124819
Substrate/Competitorn/a
Meas. Tech.ChEBML_105151
IC50 5.9±n/a nM
Citation Jarvest, RLBerge, JMBrown, MJBrown, PElder, JSForrest, AKHouge-Frydrych, CSO'Hanlon, PJMcNair, DJRittenhouse, SSheppard, RJ Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. Bioorg Med Chem Lett13:665-8 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Methionine--tRNA ligase
Name:Methionine--tRNA ligase
Synonyms:Methionyl-tRNA synthetase | SYM_ECOLI | metG
Type:PROTEIN
Mol. Mass.:76245.79
Organism:Escherichia coli (strain K12)
Description:ChEMBL_400681
Residue:677
Sequence:
MTQVAKKILVTCALPYANGSIHLGHMLEHIQADVWVRYQRMRGHEVNFICADDAHGTPIM
LKAQQLGITPEQMIGEMSQEHQTDFAGFNISYDNYHSTHSEENRQLSELIYSRLKENGFI
KNRTISQLYDPEKGMFLPDRFVKGTCPKCKSPDQYGDNCEVCGATYSPTELIEPKSVVSG
ATPVMRDSEHFFFDLPSFSEMLQAWTRSGALQEQVANKMQEWFESGLQQWDISRDAPYFG
FEIPNAPGKYFYVWLDAPIGYMGSFKNLCDKRGDSVSFDEYWKKDSTAELYHFIGKDIVY
FHSLFWPAMLEGSNFRKPSNLFVHGYVTVNGAKMSKSRGTFIKASTWLNHFDADSLRYYY
TAKLSSRIDDIDLNLEDFVQRVNADIVNKVVNLASRNAGFINKRFDGVLASELADPQLYK
TFTDAAEVIGEAWESREFGKAVREIMALADLANRYVDEQAPWVVAKQEGRDADLQAICSM
GINLFRVLMTYLKPVLPKLTERAEAFLNTELTWDGIQQPLLGHKVNPFKALYNRIDMRQV
EALVEASKEEVKAAAAPVTGPLADDPIQETITFDDFAKVDLRVALIENAEFVEGSDKLLR
LTLDLGGEKRNVFSGIRSAYPDPQALIGRHTIMVANLAPRKMRFGISEGMVMAAGPGGKD
IFLLSPDAGAKPGHQVK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50124819
n/a
NameBDBM50124819
Synonyms:2-[3-(5-Bromo-2-ethoxy-3-iodo-benzylamino)-propylamino]-1H-quinolin-4-one | CHEMBL157996
TypeSmall organic molecule
Emp. Form.C21H23BrIN3O2
Mol. Mass.556.235
SMILESCCOc1c(I)cc(Br)cc1CNCCCNc1cc(O)c2ccccc2n1
Structure
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