| Reaction Details |
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 | Report a problem with these data |
| Target | D(4) dopamine receptor |
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| Ligand | BDBM50124934 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_60995 |
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| Ki | 9±n/a nM |
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| Citation |  Zhao, H; Zhang, X; Hodgetts, K; Thurkauf, A; Hammer, J; Chandrasekhar, J; Kieltyka, A; Brodbeck, R; Rachwal, S; Primus, R; Manly, C Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist. Bioorg Med Chem Lett13:701-4 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| D(4) dopamine receptor |
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| Name: | D(4) dopamine receptor |
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| Synonyms: | D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 48373.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21917 |
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| Residue: | 419 |
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| Sequence: | MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVA
TERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCT
ASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGR
DPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSG
PGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPG
LPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWT
PFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
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| BDBM50124934 |
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| n/a |
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| Name | BDBM50124934 |
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| Synonyms: | 5-[4-(4-Chloro-benzyl)-piperazin-1-yl]-2-methyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one | CHEMBL349833 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28ClN3O |
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| Mol. Mass. | 409.952 |
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| SMILES | CC1Cc2cccc3CCC(N4CCN(Cc5ccc(Cl)cc5)CC4)C(=O)N1c23 |
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| Structure | 
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