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TargetPlatelet-activating factor acetylhydrolase
LigandBDBM50125267
Substrate/Competitorn/a
Meas. Tech.ChEBML_101008
IC50 0.250000±n/a nM
Citation Blackie, JABloomer, JCBrown, MJCheng, HYHammond, BHickey, DMIfe, RJLeach, CALewis, VAMacphee, CHMilliner, KJMoores, KEPinto, ILSmith, SAStansfield, IGStanway, SJTaylor, MATheobald, CJ The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg Med Chem Lett13:1067-70 (2003) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Platelet-activating factor acetylhydrolase
Name:Platelet-activating factor acetylhydrolase
Synonyms:1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase
Type:PROTEIN
Mol. Mass.:50084.41
Organism:Homo sapiens (Human)
Description:ChEMBL_156212
Residue:441
Sequence:
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50125267
n/a
NameBDBM50125267
Synonyms:CHEMBL10501 | N-(4'-Chloro-biphenyl-4-ylmethyl)-N-(2-diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulfanyl)-4-oxo-5,6,7,8-tetrahydro-4H-quinazolin-1-yl]-acetamide
TypeSmall organic molecule
Emp. Form.C36H40ClFN4O2S
Mol. Mass.647.245
SMILESCCN(CC)CCN(Cc1ccc(cc1)-c1ccc(Cl)cc1)C(=O)Cn1c(SCc2ccc(F)cc2)nc(=O)c2CCCCc12
Structure
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