| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Endothelin-1 receptor |
|---|
| Ligand | BDBM50125348 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_65644 |
|---|
| Ki | 22±n/a nM |
|---|
| Citation |  Tellew, JE; Baska, RA; Beyer, SM; Carlson, KE; Cornelius, LA; Fadnis, L; Gu, Z; Kunst, BL; Kowala, MC; Monshizadegan, H; Murugesan, N; Ryan, CS; Valentine, MT; Yang, Y; Macor, JE Discovery of 4'-[(imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/angiotensin II receptor antagonists. Bioorg Med Chem Lett13:1093-6 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Endothelin-1 receptor |
|---|
| Name: | Endothelin-1 receptor |
|---|
| Synonyms: | EDNRA | EDNRA_HUMAN | ET-A | ETA | ETA-R | ETRA | Endothelin receptor type A | Endothelin receptor, ET-A/ET-B | hET-AR |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 48736.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25101 |
|---|
| Residue: | 427 |
|---|
| Sequence: | METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLP
SNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRS
SHKDSMN
|
|
|
|---|
| BDBM50125348 |
|---|
| n/a |
|---|
| Name | BDBM50125348 |
|---|
| Synonyms: | 3-[2'-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-2-ethoxymethyl-biphenyl-4-ylmethyl]-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid methylamide | CHEMBL12557 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H39N5O5S |
|---|
| Mol. Mass. | 593.737 |
|---|
| SMILES | CCCc1nc(CC)c(C(=O)NC)n1Cc1ccc(c(COCC)c1)-c1ccccc1S(=O)(=O)Nc1onc(C)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
