Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50108441 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_145338 (CHEMBL750573) |
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IC50 | >10000±n/a nM |
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Citation | Semple, G; Andersson, BM; Chhajlani, V; Georgsson, J; Johansson, MJ; Rosenquist, A; Swanson, L Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods. Bioorg Med Chem Lett13:1141-5 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50108441 |
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n/a |
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Name | BDBM50108441 |
Synonyms: | 3-Phenyl-1-(1-phenyl-2-pyrrolidin-1-yl-ethyl)-1H-pyridin-2-one | CHEMBL278268 |
Type | Small organic molecule |
Emp. Form. | C23H24N2O |
Mol. Mass. | 344.4495 |
SMILES | O=c1c(cccn1C(CN1CCCC1)c1ccccc1)-c1ccccc1 |
Structure |
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