Reaction Details |
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Target | Melatonin receptor type 1A |
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Ligand | BDBM50035179 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_105097 (CHEMBL714104) |
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Ki | 0.06±n/a nM |
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Citation | Descamps-François, C; Yous, S; Chavatte, P; Audinot, V; Bonnaud, A; Boutin, JA; Delagrange, P; Bennejean, C; Renard, P; Lesieur, D Design and synthesis of naphthalenic dimers as selective MT1 melatoninergic ligands. J Med Chem46:1127-9 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melatonin receptor type 1A |
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Name: | Melatonin receptor type 1A |
Synonyms: | MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A |
Type: | Enzyme |
Mol. Mass.: | 39392.94 |
Organism: | Homo sapiens (Human) |
Description: | P48039 |
Residue: | 350 |
Sequence: | MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
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BDBM50035179 |
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n/a |
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Name | BDBM50035179 |
Synonyms: | Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide | N-[2-(7-Methoxy-naphthalen-1-yl)-ethyl]-acetamide(Agomelatine) | S 20098 | US10781182, Compound IA2-76 | US11091445, Compound code IA2-76 |
Type | Small organic molecule |
Emp. Form. | C15H17NO2 |
Mol. Mass. | 243.301 |
SMILES | COc1ccc2cccc(CCNC(C)=O)c2c1 |
Structure |
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