Reaction Details |
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Target | Geranylgeranyl transferase type-1 subunit beta |
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Ligand | BDBM50126034 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_71792 |
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IC50 | >10000±n/a nM |
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Citation | Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor. Bioorg Med Chem Lett13:1293-6 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl transferase type-1 subunit beta |
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Name: | Geranylgeranyl transferase type-1 subunit beta |
Synonyms: | 2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta |
Type: | n/a |
Mol. Mass.: | 42369.84 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 377 |
Sequence: | MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
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BDBM50126034 |
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n/a |
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Name | BDBM50126034 |
Synonyms: | 4-[1-Hydroxy-3-(3'-methoxy-5-pentanoyl-biphenyl-2-yl)-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-benzonitrile | CHEMBL26511 |
Type | Small organic molecule |
Emp. Form. | C32H29N3O3 |
Mol. Mass. | 503.591 |
SMILES | CCCCC(=O)c1ccc(C#CC(O)(c2cncn2C)c2ccc(cc2)C#N)c(c1)-c1cccc(OC)c1 |
Structure |
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