| Reaction Details |
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 | Report a problem with these data |
| Target | Geranylgeranyl transferase type-1 subunit beta |
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| Ligand | BDBM50126038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_71792 |
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| IC50 | 1800±n/a nM |
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| Citation |  Lin, NH; Wang, L; Cohen, J; Gu, WZ; Frost, D; Zhang, H; Rosenberg, S; Sham, H Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor. Bioorg Med Chem Lett13:1293-6 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Geranylgeranyl transferase type-1 subunit beta |
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| Name: | Geranylgeranyl transferase type-1 subunit beta |
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| Synonyms: | 2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta |
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| Type: | n/a |
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| Mol. Mass.: | 42369.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 377 |
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| Sequence: | MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
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|
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| BDBM50126038 |
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| n/a |
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| Name | BDBM50126038 |
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| Synonyms: | 5-[1-Hydroxy-1-(3-methyl-3H-imidazol-4-yl)-3-phenyl-propyl]-2'-methyl-biphenyl-2-carbonitrile | CHEMBL26492 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H25N3O |
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| Mol. Mass. | 407.5069 |
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| SMILES | Cc1ccccc1-c1cc(ccc1C#N)C(O)(CCc1ccccc1)c1cncn1C |
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| Structure | 
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