| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Ligand | BDBM50126340 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_69849 (CHEMBL680439) |
|---|
| IC50 | 0.450000±n/a nM |
|---|
| Citation |  Curtin, ML; Florjancic, AS; Cohen, J; Gu, WZ; Frost, DJ; Muchmore, SW; Sham, HL Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase. Bioorg Med Chem Lett13:1367-71 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Name: | Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Synonyms: | Protein Farnesyltransferase (PFT) | Protein farnesyltransferase |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | Purified bovine brain FTase. |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
|---|
| Synonyms: | CAAX farnesyltransferase alpha subunit | FNTA | FNTA_BOVIN | FTase-alpha | GGTase-I-alpha | Geranylgeranyl Transferase (GGTase-I) Chain A | Protein Farnesyltransferase (PFT) Chain A | Protein farnesyltransferase | Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit | Ras proteins prenyltransferase alpha | Type I protein geranyl-geranyltransferase alpha subunit |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 43827.38 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | The enzyme was purified from a bovine brain homogenate by sequential ammonium sulfate fractionation and affinity chromatography. |
|---|
| Residue: | 375 |
|---|
| Sequence: | MAAADGVGEAAQGGDPGQPEPPPPPQPHPPPPPPQPPQEEAAAASPIDDGFLSLDSPTYV
LYRDRPEWADIDPVPQNDGPNPVVQIIYSEKFQDVYDYFRAVLQRDERSERAFKLTRDAI
ELNAANYTVWHFRRVLLKSLQKDLHEEMNYISAIIEEQPKNYQVWHHRRVLVEWLRDPSQ
ELEFIADILTQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVI
SNTTGYNDRAILEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQP
SHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQ
SKHSTESDPPTNVQQ
|
|
|
|---|
| Component 2 |
| Name: | Protein farnesyltransferase subunit beta |
|---|
| Synonyms: | CAAX farnesyltransferase subunit beta | FNTB | FNTB_BOVIN | FTase-beta | Protein farnesyltransferase | Protein farnesyltransferase beta subunit | Protein farnesyltransferase subunit beta | RAS proteins prenyltransferase beta | Ras proteins prenyltransferase subunit beta |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 48758.49 |
|---|
| Organism: | Bos taurus (bovine) |
|---|
| Description: | Protein farnesyltransferase subunit beta |
|---|
| Residue: | 437 |
|---|
| Sequence: | MASPSSFTYCCPPSSSPIWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
MVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDVINREKLLQY
LYSLKQPDGSFLMHDGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSRWMFHQQALQEYILMCCQCPTGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATMHFLQKPV
PGFEEHEDEASAEPATD
|
|
|
|---|
| BDBM50126340 |
|---|
| n/a |
|---|
| Name | BDBM50126340 |
|---|
| Synonyms: | 4-[(3-Cyano-benzyl)-(3-methyl-3H-imidazol-4-ylmethyl)-amino]-2-naphthalen-1-yl-benzonitrile | CHEMBL431884 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H23ClN4 |
|---|
| Mol. Mass. | 462.973 |
|---|
| SMILES | Cn1cncc1CN(Cc1cccc(Cl)c1)c1ccc(C#N)c(c1)-c1cccc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
