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TargetTyrosine-protein kinase Lck
LigandBDBM50126747
Substrate/Competitorn/a
Meas. Tech.ChEMBL_221314 (CHEMBL841204)
IC50 120±n/a nM
Citation Goldberg, DRButz, TCardozo, MGEckner, RJHammach, AHuang, JJakes, SKapadia, SKashem, MLukas, SMorwick, TMPanzenbeck, MPatel, UPav, SPeet, GWPeterson, JDProkopowicz, ASSnow, RJSellati, RTakahashi, HTan, JTschantz, MAWang, XJWang, YWolak, JXiong, PMoss, N Optimization of 2-phenylaminoimidazo[4,5-h]isoquinolin-9-ones: orally active inhibitors of lck kinase. J Med Chem46:1337-49 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase Lck
Name:Tyrosine-protein kinase Lck
Synonyms:2.7.10.2 | LCK | LCK_HUMAN | LSK | Leukocyte C-terminal Src kinase | Lymphocyte cell-specific protein-tyrosine kinase | Lymphocyte-specific protein tyrosine kinase | P56-LCK | Protein YT16 | Proto-oncogene Lck | Proto-oncogene tyrosine-protein kinase LCK | Src/Lck kinase | T cell-specific protein-tyrosine kinase
Type:n/a
Mol. Mass.:57987.83
Organism:Homo sapiens (Human)
Description:P06239
Residue:509
Sequence:
MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP
LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN
SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH
YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV
PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL
VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY
IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK
SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER
PEDRPTFDYLRSVLEDFFTATEGQYQPQP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50126747
n/a
NameBDBM50126747
Synonyms:2-(2,6-Dichloro-phenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxo-ethyl)-1,8-dihydro-imidazo[4,5-h]isoquinolin-9-one | CHEMBL281675
TypeSmall organic molecule
Emp. Form.C24H23Cl2N5O3
Mol. Mass.500.377
SMILESCc1[nH]c(=O)c2c3n(C)c(Nc4c(Cl)cccc4Cl)nc3ccc2c1CC(=O)N1CCOCC1
Structure
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