| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C alpha type |
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| Ligand | BDBM50100126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_160296 (CHEMBL769624) |
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| Ki | 31±n/a nM |
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| Citation |  Sigano, DM; Peach, ML; Nacro, K; Choi, Y; Lewin, NE; Nicklaus, MC; Blumberg, PM; Marquez, VE Differential binding modes of diacylglycerol (DAG) and DAG lactones to protein kinase C (PK-C). J Med Chem46:1571-9 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C alpha type |
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| Name: | Protein kinase C alpha type |
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| Synonyms: | KPCA_HUMAN | PKC alpha | PKC alpha and beta-2 | PKC-A | PKC-alpha | PKCA | PRKACA | PRKCA | Protein Kinase C- alpha | Protein kinase C alpha | Protein kinase C alpha (PKCa) | Protein kinase C alpha type (PKC-A) | Protein kinase C alpha type (PRKCA) | Proto-oncogene c-RAF | RAF proto-oncogene serine/threonine-protein kinase |
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| Type: | Enzyme |
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| Mol. Mass.: | 76755.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 672 |
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| Sequence: | MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS
LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA
KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL
SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME
LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG
TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA
DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG
EDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRI
DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN
PQFVHPILQSAV
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| BDBM50100126 |
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| n/a |
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| Name | BDBM50100126 |
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| Synonyms: | 3-Isopropyl-4-methyl-pent-2-enoic acid 1-hydroxymethyl-2-(3-isopropyl-4-methyl-pentanoyloxy)-ethyl ester | CHEMBL38644 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H38O5 |
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| Mol. Mass. | 370.5234 |
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| SMILES | [#6]-[#6](-[#6])-[#6](-[#6]-[#6](=O)-[#8]-[#6]-[#6@H](-[#6]-[#8])-[#8]-[#6](=O)\[#6]=[#6](\[#6](-[#6])-[#6])-[#6](-[#6])-[#6])-[#6](-[#6])-[#6] |
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| Structure | 
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